| BCL2 | B-cell CLL/lymphoma 2 | 596 | Colon Cancer | LoVo | - | - | - | - | Noscapine effectively inhibited the proliferation of LoVo cells in vitro (IC50 = 75 lM). This cytotoxicity was reflected by cell cycle arrest at G2/M and subsequent apoptosis,as indicated by increased chromatin condensation and fragmentation, the upregulation of Bax and cytochrome c (Cyt-c), the downregulation of survivin and Bcl-2, and the activation of caspase-3 and caspase-9. | 22546556 |