NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Nordihydroguaiaretic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
IGF1Rinsulin-like growth factor 1 receptor3480Breast adenocarcinomaMCF-731±12 µM---Treatment of MCF-7 cells with increasing concentrations of NDGA for 1 h prior to the addition of 3 nM IGF-1produced a dose-dependent decrease in IGF-1R autophosphorylation with an IC50 of 31 ± 12 µM.16142439
IGF1Rinsulin-like growth factor 1 receptor3480Breast cancerMCNeuA----Twenty nine days post-implantation, and 16 h following the final administration the autophosphorylation of IGF-1R receptor was reduced in tumors from NDGA-treated mice compared to vehicle-treated controls. Inhibition of signaling by this receptor tyrosine kinase through treatment with NDGA in vivo was associated with a reduced tumor growth rate.16142439

 






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