Compound: Nordihydroguaiaretic acid

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

ERBB2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2

2064

Breast Carcinoma

MCNeuA

15±4 µM

MCNeuA cells, a breast cancer cell line derived from transgenic mice overexpressing the rodent form of this receptor. Exposure of these cells to increasing concentrations of NDGA produced a dose-dependent inhibition of HER2/neu autophosphorylation. Ligand-independent tyrosine phosphorylation of HER2/neu was inhibited by NDGA with an IC50 of 15 ± 4 µM

16142439

ERBB2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2

2064

Breast cancer

MCNeuA

Twenty nine days post-implantation, and 16 h following the final administration the autophosphorylation of HER2/neu receptor was reduced in tumors from NDGA-treated mice compared to vehicle-treated controls. Inhibition of signaling by this receptor tyrosine kinase through treatment with NDGA in vivo was associated with a reduced tumor growth rate.

16142439

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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