NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Nimbolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b8795Colon cancerHCT-116----The limonoid up-regulated DR5 in HCT-116 cells in a dose- and time-dependent manner . Treatment of cells with 5 M nimbolide for 12 h was found optimal for up-regulating DRs without affecting cell viabilit.21078664
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b8795Colon CancerHT-29----We examined whether nimbolide can modulate the expression of these proteins. Our results revealed that nimbolide down-regulated the expression of Bcl-2,Bcl-xL, cIAP-1, cIAP-2, I-FLICE, survivin, and XIAP. The effect of nimbolide was most prominent at 5 and 10 M. Overall, these results suggest that nimbolide can down-regulate cell survival protein.21078664

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.