NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: nimbolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ROS1c-ros oncogene 1 , receptor tyrosine kinase6098Cervix AdenocarcinomaHeLa----There is accumulating evidence to indicate that ROS plays an important role in apoptosis induction.Treatment with azadirachtin (135 µ M) and nimbolide (5 µ M) for 24 h significantly increased ROS generation in HeLa cells compared to control.20429769

 






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