NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: nimbolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon9641Cervix AdenocarcinomaHeLa----To investigate the effects of azadirachtin (135 µ M)and nimbolide (5 µ M) on the expression of markers associated with cell survival, proliferation and apoptosis, we analysed the mRNA and protein expression.Quantifi cation of each band by densitometric analysis revealed signifi cant. with decrease in the expression of cyclin D1,PCNA, NF- k B, p-I k B- a , IKK b , survivin, Bcl-2, Bcl-xL, Mcl-1 and mitochondrial cytochrome c in HeLa cells treated with azadirachtin and nimbolide compared to untreated control.20429769

 






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