NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: nimbolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Colon CancerHT-29----HT-29 cells exposed to nimbolide showed G2/M phase arrest, up-regulation of p21.20429769
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Cervix AdenocarcinomaHeLa----To investigate the effects of azadirachtin (135 µ M)and nimbolide (5 µ M) on the expression of markers associated with cell survival, proliferation and apoptosis, we analysed the mRNA and protein expression. Quantifi cation of each band by densitometric analysis revealed signifi cant increase in the expression of p53,p21, I k B, Bid, Bad, Bax, cytosolic cytochrome C,Apaf-1, caspase -2L, -6, -8, -9 and -3 and PARP cleavage.20429769

 






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