NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Nimbolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Colon cancerHCT-116----Nimbolide up-regulated the expression of Bax and cytochrome c in a dose-dependent manner. Levels of Bid, a pro-apoptotic Bcl-2 family protein that is cleaved by caspase-8 to truncated Bid was also decreased in a dose-dependent manner.These results suggest that nimbolide can up-regulate pro-apoptotic protein.21078664
BAXBCL2-associated X protein581Cervix AdenocarcinomaHeLa----To investigate the effects of azadirachtin (135 µ M)and nimbolide (5 µ M) on the expression of markers associated with cell survival, proliferation and apoptosis, we analysed the mRNA and protein expression. Quantifi cation of each band by densitometric analysis revealed signifi cant increase in the expression of p53,p21, I k B, Bid, Bad, Bax, cytosolic cytochrome C,Apaf-1, caspase -2L, -6, -8, -9 and -3 and PARP cleavage.20429769

 






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