NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Naringenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NQO1NAD(P)H dehydrogenase, quinone 11728Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7>50 µM---It induces the QR activity.Induction of phases 2 enzymes contributes to chemopreventive activity. QR is not catalyzing a conjugation reaction, but it is induced co-ordinately with other phase 2 enzymes and contributes to detoxification by reduction of reactive quinones to less reactive hydroquinones.Phytochemistry Reviews 1: 369-377, 2002

 






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