NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Myricetin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MAP2K4mitogen-activated protein kinase kinase 46416Skin CarcinomaSKH-1----Myricetin can bind with MKK4 directly and that it attenuated tumor necrosis factor-alpha (TNF-a)-induced JNK and ERK phosphorylation, AP-1 activation, and VEGFexpression. Myricetin fits easily into the ATP-binding site of MKK4, located between the N- and C-lobes of the kinase domain. 21793847

 






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