NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Menthol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Gastric CarcinomaSNU-5----Western blot D427 analysis revealed that (-)-Menthol treatment decreased topoisomeraseI, IIalpha;IIbeta and NF-Î B protein levels. Menthol treatment decreased topoisomerase I, IIalphaIIIalpha;IIIbeta‚and NF-Î B levels of gene expression. The effects of (-)-Menthol on the gene expression of topoisomerase I, IIalpha;IIbeta;IIIalpha;IIIbeta‚and NF-Î B from SNU-5 cells were also confirmed by cDNA microarray.16158947
RAP1ARAP1A, member of RAS oncogene family5906LeukemiaK-562----Menthol was found to decrease the up-regulation of Rap1a.12671036
RHOBras homolog family member B388LeukemiaK-562----Menthol was found to decrease the up-regulation of RhoB induced by Lov.12671036
TOP1MTtopoisomerase (DNA) I116447Gastric CarcinomaSNU-5----Western blot D427 analysis revealed that (-)-Menthol treatment decreased topoisomeraseI, IIalpha;IIbeta and NF-Î B protein levels. Menthol treatment decreased topoisomerase I, IIalphaIIIalpha;IIIbeta‚and NF-Î B levels of gene expression. The effects of (-)-Menthol on the gene expression of topoisomerase I, IIalpha;IIbeta;IIIalpha;IIIbeta‚and NF-Î B from SNU-5 cells were also confirmed by cDNA microarray.16158947
TOP2Atopoisomerase (DNA) II alpha 170kDa7153Gastric CarcinomaSNU-5----Western blot D427 analysis revealed that (-)-Menthol treatment decreased topoisomeraseI, IIalpha;IIbeta and NF-Î B protein levels. Menthol treatment decreased topoisomerase I, IIalphaIIIalpha;IIIbeta‚and NF-Î B levels of gene expression. The effects of (-)-Menthol on the gene expression of topoisomerase I, IIalpha;IIbeta;IIIalpha;IIIbeta‚and NF-Î B from SNU-5 cells were also confirmed by cDNA microarray.16158947
TOP2Btopoisomerase (DNA) II beta 180kDa7155Gastric CarcinomaSNU-5----Western blot D427 analysis revealed that (-)-Menthol treatment decreased topoisomeraseI, IIalpha;IIbeta and NF-Î B protein levels. Menthol treatment decreased topoisomerase I, IIalphaIIIalpha;IIIbeta‚and NF-Î B levels of gene expression. The effects of (-)-Menthol on the gene expression of topoisomerase I, IIalpha;IIbeta;IIIalpha;IIIbeta‚and NF-Î B from SNU-5 cells were also confirmed by cDNA microarray.16158947

 






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