NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Matrine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Pancreatic AdenocarcinomaBxPC-3----Matrine treatment upregulated the expression of Bax20930385
BAXBCL2-associated X protein581Pancreatic CancerPANC-1----Matrine treatment upregulated the expression of Bax20930385
BCL2B-cell CLL/lymphoma 2596Pancreatic AdenocarcinomaBxPC-3----Matrine downregulated the expression of Bcl-220930385
BCL2B-cell CLL/lymphoma 2596Pancreatic CancerPANC-1----Matrine downregulated the expression of Bcl-220930385
CASP3caspase 3, apoptosis-related cysteine peptidase836Pancreatic AdenocarcinomaBxPC-3----Matrine increased the activation of caspase-3 in dose-dependent manner20930385
CASP3caspase 3, apoptosis-related cysteine peptidase836Pancreatic CancerPANC-1----Matrine increased the activation of caspase-3 in dose-dependent manner20930385
CASP8caspase 8, apoptosis-related cysteine peptidase841Pancreatic AdenocarcinomaBxPC-3----Matrine increased the activation of caspase-8 in dose-dependent manner20930385
CASP8caspase 8, apoptosis-related cysteine peptidase841Pancreatic CancerPANC-1----Matrine increased the activation of caspase-8 in dose-dependent manner20930385
CASP9caspase 9, apoptosis-related cysteine peptidase842Pancreatic AdenocarcinomaBxPC-3----Matrine increased the activation of caspase-9 in dose-dependent manner20930385
CASP9caspase 9, apoptosis-related cysteine peptidase842Pancreatic CancerPANC-1----Matrine increased the activation of caspase-9 in dose-dependent manner20930385
FasTNF receptor superfamily, member 6355Pancreatic AdenocarcinomaBxPC-3----Matrine upregulated the expression of Fas20930385
FasTNF receptor superfamily, member 6355Pancreatic CancerPANC-1----Matrine upregulated the expression of Fas20930385
PCNAproliferating cell nuclear antigen5111Pancreatic AdenocarcinomaBxPC-3----Matrine downregulated the expression of PCNA in a dose-dependent manner.20930385
PCNAproliferating cell nuclear antigen5111Pancreatic CancerPANC-1----Matrine downregulated the expression of PCNA in a dose-dependent manner.20930385

 






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