NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: maslinic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP8caspase 8, apoptosis-related cysteine peptidase841Colon CancerHT-29----We found that in HT29 cells maslinic acid activated the expression of c-Jun NH2-terminal kinase (JNK), thus inducing p53. Treatment of tumor cells with maslinic acid also resulted in an increase in the expression of Bid and Bax, repression of Bcl-2, release of cytochrome-c and an increase in the expression of caspases -9, -3, and -7. Moreover, maslinic acid produced belated caspase-8 activity, thus amplifying the initial mitochondrial apoptotic signaling.21524306

 






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