NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Lycopene

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ABCA1ATP-binding cassette, sub-family A (ABC1), member 119Prostate CancerLNCaP----increased in the expression of ATP-binding cassette transporter 1 (ABCA1) was only evident 96 h.21334870
NR1H3nuclear receptor subfamily 1, group H, member 310062Prostate CancerLNCaP----lycopene treatment (2.5-10 µM) significantly inhibited the proliferation of LNCaP cells during incubation for 96 h. Lycopene significantly increased the protein and mRNA expression of LXRalpha at 48 h.21334870
PPARGperoxisome proliferator-activated receptor gamma5468Prostate CancerLNCaP----lycopene treatment (2.5-10 µM) significantly inhibited the proliferation of LNCaP cells during incubation for 96 h. Lycopene significantly increased the protein and mRNA expression of PPAR gamma at 24 and 48 h.21334870

 






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