NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Liquiritigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Hepatocellular carcinomaSMMC-7721----The level of Bcl-2 protein significantly decreased in a time-dependent manner after liquiritigenin treatment, which gradually disappeared at 72 h.And the ratio of Bcl-2/b-actin band densities was observed in a time-dependent decrease significantly.19150383
CASP3caspase 3, apoptosis-related cysteine peptidase836Hepatocellular carcinomaSMMC-7721----Caspase-3 plays a central role in mediating various apoptotic responses. In this study, caspase-3 protease activity significantly increased in a time-dependent manner after liquiritigenin treatment. 0.4 mM liquiritigenin strongly induced activation of caspae-3 protease as early as 24 h, and the maximum activity at 72 h was 773.94 ± 31.04%, which was about 7-fold increase compared with control.19150383
CASP3caspase 3, apoptosis-related cysteine peptidase836Liver CancerHUH7----Compound showed at least a 50%increase in caspase activity showing the ability of these flavonoids to induce apoptosis in HuH-7 cells21495101
GPX1glutathione peroxidase 12876Hepatocellular carcinomaSMMC-7721----The data show that activities of Glutathione Peroxidase decreased in time-dependent manner after cells treated with 0.4 mM liquiritigenin. And the GSH-PX activities significantly decreased at 24, 48 and 72 h (p< 0.05), which decreased to 15.4 ± 4.7 U (72 h) from 37.7 ± 2.9 U (0 h.19150383
SOD1superoxide dismutase 16647Hepatocellular carcinomaSMMC-7721----The data show that activities of Superoxide Dismutase(SOD) decreased in time-dependent manner after cells treated with 0.4 mM liquiritigeni.19150383
TP53tumor protein p537157Hepatocellular carcinomaSMMC-7721----0.4 mM liquiritigenin induced a significant increase in the expression of p53. The level of p53 increased significantly when SMMC7721cells were treated with 0.4 mM liquiritigenin for 12 h, and remained elevated until 72 h.Densitometric analysis showed the increases in the ratio of p53/b-actin band densities reached statistical significance at 48 h(2.0-fold, p < 0.05) and 72 h (2.4-fold, p < 0.01).19150383
VEGFAvascular endothelial growth factor A7422Cervical cancerHeLa----Liquiritigenin effectively inhibited the growth of tumors xenografted in nude mice from human cervical cancer cell line HeLa cells. From the analysis it was concluded that liquiritigenin could suppress the proliferation of tumor cells by inhibiting VEGF expression to prevent the angiogenesis of tumors.22692244

 






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