NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Linalool

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207LeukemiaMolt-4----Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of PKB alpha by 15.63 fold19922762
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026LeukemiaMolt-4----treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12 .19922762
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)1027LeukemiaMolt-4----treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12 .19922762
CDKN1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)1028LeukemiaMolt-4----treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12 .19922762
CDKN2Bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)1030LeukemiaMolt-4----treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of a variety of cyclin-dependent kinase inhibitors, such as p21Waf1/CIP1 (31.4 fold), p27Kip1 (43.0 fold), P57Kip2 (32.46 fold), p15 (4.0 fold) at 12 .19922762
CSN2casein beta1447LeukemiaMolt-4----Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of Beta-casein by 14.0 fold19922762
EDN1endothelin 11906LeukemiaMolt-4----Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of EDN1 by 26.23 fold19922762
FN1fibronectin 12335LeukemiaMolt-4----Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of FN1 by 19.41 fold19922762
GADD45Agrowth arrest and DNA-damage-inducible, alpha1647LeukemiaMolt-4----linalool treatment triggered the activation of p53 tumor suppressor and cyclin-dependent kinase inhibitors (such as p21Waf1, p27Kip1, P57Kip2), which results in the induction of GADD45 /JNK signaling pathway. P5.19922762
HSPA4heat shock 70kDa protein 43308LeukemiaMolt-4----Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of Hsp70 by 10.97 fold19922762
HSPB2heat shock 27kDa protein 23316LeukemiaMolt-4----Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of HSPB2 by 56.55 fold19922762
MAPK8mitogen-activated protein kinase 85599LeukemiaMolt-4----linalool treatment triggered the activation of p53 tumor suppressor and cyclin-dependent kinase inhibitors (such as p21Waf1, p27Kip1, P57Kip2), which results in the induction of GADD45 /JNK signaling pathway. P5.19922762
MDM2Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)4193LeukemiaMolt-4----Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of MDM2 by 12.46 fold19922762
MYCv-myc myelocytomatosis viral oncogene4609LeukemiaMolt-4----Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of c-Myc by 50.48 fold19922762
TP53tumor protein p537157LeukemiaMolt-4----linalool treatment triggered the activation of p53 tumor suppressorwhich results in the induction of GADD45 /JNK signaling pathway. P5.19922762
WSB1WD repeat and SOCS box containing 126118LeukemiaMolt-4----Results revealed that treatment of Molt-4 leukemia cells with linalool (130 M) resulted in a time-dependent increase in mRNA expression of SWIP-1/DKFZp564A122 by 32.73 fold19922762

 






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