NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Licochalcone A

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

RB1

retinoblastoma 1

5925

Gastric Cancer

AGS

-

-

-

-

Rb also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent increase in Rb and a decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of Rb in gastric cancer cells.

21216524

RB1

retinoblastoma 1

5925

Gastric Cancer

MKN-28

-

-

-

-

Rb also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent increase in Rb and a decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of Rb in gastric cancer cells.

21216524

RB1

retinoblastoma 1

5925

Gastric Cancer

MKN-45

-

-

-

-

Rb also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent increase in Rb and a decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of Rb in gastric cancer cells.

21216524

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.