NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Licochalcone A

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MDM2Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)4193Gastric CancerAGS----Licochalcone A inhibited the expression of matrix metalloproteinase-9 in the liver. And MMP-9 has known role in colon cancer metastasis.21216524
MDM2Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)4193Gastric CancerMKN-28----MDM2 also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of MDM2 in gastric cancer cells.21216524
MDM2Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)4193Gastric CancerMKN-45----MDM2 also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of MDM2 in gastric cancer cells.21216524

 






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