NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Licochalcone A

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Gastric CancerAGS----Licochalcone A-induced apoptosis by its effects on the expression of Bax.21216524
BAXBCL2-associated X protein581Gastric CancerMKN-28----Licochalcone A-induced apoptosis by its effects on the expression of Bax.21216524
BAXBCL2-associated X protein581Gastric CancerMKN-45----Licochalcone A-induced apoptosis by its effects on the expression of Bax.21216524
BCL2B-cell CLL/lymphoma 2596Prostate CancerLNCaP----Immunoblot analysis reveals that treatment with licorice in LNCaP cells down-regulated the expression of Bcl-2 with concomitant enhancement of the conversion of LC3-I to LC3-II, which is indicative of autophagic induction.19711916
BCL2B-cell CLL/lymphoma 2596Gastric CancerAGS----Licochalcone A-induced apoptosis by its effects on the expression of Bcl-221216524
BCL2B-cell CLL/lymphoma 2596Gastric CancerMKN-28----Licochalcone A-induced apoptosis by its effects on the expression of Bcl-221216524
BCL2B-cell CLL/lymphoma 2596Gastric CancerMKN-45----Licochalcone A-induced apoptosis by its effects on the expression of Bcl-221216524
CASP3caspase 3, apoptosis-related cysteine peptidase836Gastric CancerAGS----Exposure of gastric cancer cells to Licochalcone A resulted in a dose-dependent decrease in unactivated caspase-3. This indicates that the canonical mitochondrial apoptotic pathway is activated by Licochalcone A21216524
CASP3caspase 3, apoptosis-related cysteine peptidase836Gastric CancerMKN-28----Exposure of gastric cancer cells to Licochalcone A resulted in a dose-dependent decrease in unactivated caspase-3. This indicates that the canonical mitochondrial apoptotic pathway is activated by Licochalcone A21216524
CASP3caspase 3, apoptosis-related cysteine peptidase836Gastric CancerMKN-45----Exposure of gastric cancer cells to Licochalcone A resulted in a dose-dependent decrease in unactivated caspase-3. This indicates that the canonical mitochondrial apoptotic pathway is activated by Licochalcone A21216524
COX-2cytochrome c oxidase subunit II4513Lliver metastasisCT-26----Perturbations in the expression of proinflammatory mediators, including COX-2, is also found in colon carcinogenesis.Licochalcone A treatment (30 mg/kg) also reduced the expression of these enzyme.20383690
CTNNBIP1catenin, beta interacting protein 156998Lliver metastasisCT-26----Since accumulation of activated Beta-catenin in the nucleus is particularly relevant in colon cancer, they determined the expression of Beta-catenin.Licochalcone A treatment decreased nuclear Beta-catenin staining in adenocarcinoma cells.20383690
CycACyclin A39340Gastric CancerAGS----Treatment with Licochalcone A, resulted in a substantial reduction in the expression of cyclin A in MKN-45 and MKN-28 cells. These observations suggest that this decrease in cyclin A expression may play an important role inLicochalcone A-induced G2/M arrest in human gastric cancer cells.21216524
CycACyclin A39340Gastric CancerMKN-28----Treatment with Licochalcone A, resulted in a substantial reduction in the expression of cyclin A in MKN-45 and MKN-28 cells. These observations suggest that this decrease in cyclin A expression may play an important role inLicochalcone A-induced G2/M arrest in human gastric cancer cells.21216524
CycACyclin A39340Gastric CancerMKN-45----Treatment with Licochalcone A, resulted in a substantial reduction in the expression of cyclin A in MKN-45 and MKN-28 cells. These observations suggest that this decrease in cyclin A expression may play an important role inLicochalcone A-induced G2/M arrest in human gastric cancer cells.21216524
CycBCyclin B37618Gastric CancerAGS----Treatment with Licochalcone A, resulted in a substantial reduction in the expression of cyclin B in MKN-45 and MKN-28 cells. These observations suggest that this decrease in cyclin B expression may play an important role inLicochalcone A-induced G2/M arrest in human gastric cancer cells.21216524
CycBCyclin B37618Gastric CancerMKN-28----Treatment with Licochalcone A, resulted in a substantial reduction in the expression of cyclin B in MKN-45 and MKN-28 cells. These observations suggest that this decrease in cyclin B expression may play an important role inLicochalcone A-induced G2/M arrest in human gastric cancer cells.21216524
CycBCyclin B37618Gastric CancerMKN-45----Treatment with Licochalcone A, resulted in a substantial reduction in the expression of cyclin B in MKN-45 and MKN-28 cells. These observations suggest that this decrease in cyclin B expression may play an important role inLicochalcone A-induced G2/M arrest in human gastric cancer cells.21216524
MDM2Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)4193Gastric CancerAGS----Licochalcone A inhibited the expression of matrix metalloproteinase-9 in the liver. And MMP-9 has known role in colon cancer metastasis.21216524
MDM2Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)4193Gastric CancerMKN-28----MDM2 also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of MDM2 in gastric cancer cells.21216524
MDM2Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)4193Gastric CancerMKN-45----MDM2 also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of MDM2 in gastric cancer cells.21216524
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Lliver metastasisCT-26----MDM2 also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of MDM2 in gastric cancer cells.20383690
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792Lliver metastasisCT-26----Licochalcone A suppresses inflammation by blocking NF-kappaB signal, they determined the degradation of Ik-Balpha in colonic tissues by western blot analysis. Licochalcone A treatment blocked Ik-Balpha degradation in AOM/DSS-treated colonic tissues .20383690
NOS2nitric oxide synthase 2, inducible4843Lliver metastasisCT-26----Perturbations in the expression of proinflammatory mediators, including iNOS, is also found in colon carcinogenesis. LicA treatment (30 mg/kg) also reduced the expression of these enzyme.20383690
PARP1poly (ADP-ribose) polymerase 1142Gastric CancerAGS----Licochalcone A-induced apoptosis by its effects on the expression of PARP21216524
PARP1poly (ADP-ribose) polymerase 1142Gastric CancerMKN-28----Licochalcone A-induced apoptosis by its effects on the expression of PARP21216524
PARP1poly (ADP-ribose) polymerase 1142Gastric CancerMKN-45----Licochalcone A-induced apoptosis by its effects on the expression of PARP21216524
RB1retinoblastoma 15925Gastric CancerAGS----Rb also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent increase in Rb and a decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of Rb in gastric cancer cells.21216524
RB1retinoblastoma 15925Gastric CancerMKN-28----Rb also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent increase in Rb and a decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of Rb in gastric cancer cells.21216524
RB1retinoblastoma 15925Gastric CancerMKN-45----Rb also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent increase in Rb and a decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of Rb in gastric cancer cells.21216524

 






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