NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Kaempferol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 36197Colon cancerHCT-116----NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application.19435896
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 36197Epidermoid carcinoma A-431----NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application.19435896
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 36197MelanomaSK-MEL-28----NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application.19435896
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 36197MelanomaSK-MEL-5----NTD RSK2 is a critical kinase domain for substrate phosphorylation, which requires ERK-mediated activation. Kaempferol binds and suppresses theactivation of NTD RSK and that Val82 and Lys100 are critical amino acids for NTD RSK2 activity and inhibition by kaempferol resulted in decreased cell proliferation. targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application.19435896

 






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