NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Isoliquiritigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
PLAUplasminogen activator, urokinase5328Prostate CancerDU-145----Isoliquiritigenin inhibited secretion of uPA protein regardless of whether the cells were treated with EGF. Results of RT-PCR revealed that EGF increased the mRNA levels of uPA, and Isoliquiritigenin decreased them irrespective of EGF treatment. And decreased secretion of this protease contributes to the decrease in invasion and migration of ISL-treated DU145 cells.18824345

 






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