NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Isoliquiritigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Prostate CancerDU-145----Isoliquiritigenin inhibited secretion of MMP-9 protein regardless of whether the cells were treated with EGF. Results of RT-PCR revealed that EGF increased the mRNA levels of MMP-9, and Isoliquiritigenin decreased them irrespective of EGF treatment. And decreased secretion of this protease contributes to the decrease in invasion and migration of ISL-treated DU145 cells.18824345

 






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