NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Isoliquiritigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MAPK8mitogen-activated protein kinase 85599Prostate CancerDU-145----Western blot analyses revealed that treating DU145 cells with EGF led to increased phosphorylation of JNK. ISL inhibited phosphorylation of JNK, they examined next whether the JNK inhibitor SP600125 inhibits DU145 cell migration. Treating cells with 10 µmol/L SP600125 led to a significant decrease in phosphorylation of 54-kDa JNK2. The JNK inhibitor significantly inhibited both basal and EGF-induced migration of DU145 cells.18824345

 






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