Compound: Honokiol

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

CASP3

caspase 3, apoptosis-related cysteine peptidase

836

Prostate Cancer

LNCaP

After honokiol treatment, we observed activated caspases 3 as exhibited by increased intensity of protein bands at 17 kDa.

17326044

CASP8

caspase 8, apoptosis-related cysteine peptidase

841

Prostate Cancer

LNCaP

After honokiol treatment, we observed activated caspases 8 as exhibited by increased intensity of protein bands at 40 kDa.

17326044

CASP9

caspase 9, apoptosis-related cysteine peptidase

842

Prostate Cancer

LNCaP

After honokiol treatment, we observed activated caspases 9, as exhibited by increased intensity of protein bands at 35 kDa.

17326044

NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

4790

Honokiol also suppressed PMA-induced NF-nB activation in ICR mice skin in vivo.

16966432

PARP1

poly (ADP-ribose) polymerase 1

142

Prostate Cancer

LNCaP

After honokiol treatment, increased cleavage of PARP in a dose- and time-dependent manner was observed.

17326044

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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