NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: homoharringtonine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Human promyelocytic leukemiaHL-60----Data, depicted that the activity of caspase-3 increased in 16 and 8 hours following treatment.18415656
CASP9caspase 9, apoptosis-related cysteine peptidase842Human promyelocytic leukemiaHL-60----Data, depicted that the activity of caspase-9 increased in 16 and 8 hours following treatment.18415656
CYCScytochrome c54205Human promyelocytic leukemiaHL-60----HHT was shown to provoke the release of the proapoptotic mitochondrial protein, cytochrome c, in a dose-dependent manne.18415656
MCL1myeloid cell leukemia sequence 1 (BCL2-related)4170MyelomaAMO-1----Among the major anti-apoptotic Bcl-2 family proteins,Mcl-1 was clearly highly expressed in AMO-1 cells18415656
MCL1myeloid cell leukemia sequence 1 (BCL2-related)4170Multiple MyelomaRPMI-8226----Among the major anti-apoptotic Bcl-2 family proteins,Mcl-1 was clearly highly expressed.18415656

 






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