NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Hesperetin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Breast adenocarcinomaMCF-7----The expression of Bcl-2 associated x protein (Bax) as markers of apoptosis. Hesperetin increased that of Bax in a dose-dependent manner at 48 h.17927510
BAXBCL2-associated X protein581Gastric CancerAGS----Western blot results showed that expression level of Bax was increased in a dose-dependent manner.22194772
BCL2B-cell CLL/lymphoma 2596Breast adenocarcinomaMCF-7----The expression of Bcl-2 as markers of apoptosis.Hesperetin decreased the expression of Bcl-2 in a dose-dependent manner at 48 .17927510
BCL2L1BCL2-like 1598Breast adenocarcinomaMCF-7----It prevented the xenograft growth by down-regulating the expression of Bcl-x(L.22209285
BCL2L1BCL2-like 1598Gastric CancerAGS----Western blot results showed that expression level of Bcl-xL was decreased in a dose-dependent manner.22194772
CASP3caspase 3, apoptosis-related cysteine peptidase836Gastric CancerAGS----Flavonoids caused downregulation of procaspase-3 which consequently increased the activity of caspase-3.22194772
CCNB1cyclin B1891Gastric CancerAGS----It reduces the protein level of cyclin B1 in a dose-dependent manner.Decrease of cyclin B1 expression might be a molecular mechanism through which flavonoids induce G2/M arrest.22194772
CCND1cyclin D1595Breast adenocarcinomaMCF-7----It prevented the xenograft growth by down-regulating the expression of cyclin D.22209285
CCND1cyclin D1595Breast adenocarcinomaMCF-7----The expression of cyclin D was inhibited after 48 h of 50 µM hesperetin.Hesperetin induced a decrease in cyclinD and CDK4, together with an increase in p21Cip1 and p27Kip1 associated with CDK4.17927510
CDC25Ccell division cycle 25 homolog C (S. pombe)995Gastric CancerAGS----It reduces the protein level of cdc 25c in a dose-dependent manner.Decrease of cdc 25c expression might be a molecular mechanism through which flavonoids induce G2/M arrest.22194772
CDK1cyclin-dependent kinase 1983Gastric CancerAGS----It reduces the protein level of cdc 2 in a dose-dependent manner.Decrease of cdc 2 expression might be a molecular mechanism through which flavonoids induce G2/M arrest.22194772
CDK2cyclin-dependent kinase 21017Breast adenocarcinomaMCF-7----Hesperetin treatment at high cncentration for 72 h resulted in a decrease in CDK2 and CDK4 together with cyclin D. A reduction in the expression of CDK2 and cyclin E was observed at the maximum concentration of 100 µM hesperetin for 72 h.17927510
CDK4cyclin-dependent kinase 41019Breast adenocarcinomaMCF-7----Hesperetin treatment resulted in a marked reduction in the expression of CDK4 in a dose-dependent manner after 48 and 72 h of treatment.17927510
CDK4cyclin-dependent kinase 41019Breast adenocarcinomaMCF-7----It prevented the xenograft growth by down-regulating the expression of CDK.22209285
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Breast adenocarcinomaMCF-7----our data suggest for the first time that the regulation of CDK4 and p21Cip1 may participate in the anticancer activity pathway of hesperetin in MCF-7 cells.17927510
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)1027Breast adenocarcinomaMCF-7----hesperetin down-regulates the cyclin-dependent kinases (CDKs) and cyclins and upregulates p21Cip1 and p27Kip1 in cells treated with hesperetin for 48 h and 72 h.17927510
CDKN1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)1028Breast adenocarcinomaMCF-7----It prevented the xenograft growth by down-regulating the expression of p57Kip.22209285
CYP19A1cytochrome P450, family 19, subfamily A, polypeptide 11588Breast adenocarcinomaMCF-75 µM---HSP inhibited aromatase enzyme activity and suppressed proliferation of MCF-7aro cells in vivo.22209285
CYP1A1cytochrome P4501543Breast cancerMCF-7----CYP1A1 expression was significantly induced by androstenedione administration, and cotreatment with HSP repressed the increase22209285
PARP1poly (ADP-ribose) polymerase 1142Gastric CancerAGS----During apoptosis, caspases induce PARP cleavage and inactivation and cleavage of PARP helps cellular disassembly and is a marker of cells undergoing apoptosis.22194772
TFF1trefoil factor 17031Breast cancerMCF-7----Dietary administration of Hesperetin(HSP) at 1000 ppm and 5000 ppm significantly deterred the xenograft growth. Dietary HSP treatment significantly (P<.05) inhibited pS2 expression induced by the exogenous androstenedione.22209285

 






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