NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: guggulsterone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CCND1cyclin D1595head and neck squamous cell carcinomaUM-22b----In UM-22b cells, expression levels of proteins that promote the transition from the G1 to the S phase of the cell cycle, including CDK4, CDK6, CDK2, phosphorylated Rb, cyclin E and cyclin D1,which is a target gene for both STAT3 and NFkappaB, showed modest decreases following 16 h of guggulsterone19762335
CCNE1cyclin E1898head and neck squamous cell carcinomaUM-22b----In UM-22b cells, expression levels of proteins that promote the transition from the G1 to the S phase of the cell cycle, including CDK4, CDK6, CDK2, phosphorylated Rb, cyclin E and cyclin D1,which is a target gene for both STAT3 and NFkappaB, showed modest decreases following 16 h of guggulsterone19762335
CDK2cyclin-dependent kinase 21017head and neck squamous cell carcinomaUM-22b----In UM-22b cells, expression levels of proteins that promote the transition from the G1 to the S phase of the cell cycle, including CDK4, CDK6, CDK2, phosphorylated Rb, cyclin E and cyclin D1,which is a target gene for both STAT3 and NFkappaB, showed modest decreases following 16 h of guggulsterone19762335
CDK6cyclin-dependent kinase 61021head and neck squamous cell carcinomaUM-22b----In UM-22b cells, expression levels of proteins that promote the transition from the G1 to the S phase of the cell cycle, including CDK4, CDK6, CDK2, phosphorylated Rb, cyclin E and cyclin D1,which is a target gene for both STAT3 and NFkappaB, showed modest decreases following 16 h of guggulsterone19762335
CDK6cyclin-dependent kinase 61021head and neck squamous cell carcinomaUM-22b----In UM-22b cells, expression levels of proteins that promote the transition from the G1 to the S phase of the cell cycle, including CDK4, CDK6, CDK2, phosphorylated Rb, cyclin E and cyclin D1,which is a target gene for both STAT3 and NFkappaB, showed modest decreases following 16 h of guggulsterone19762335
HIF1Ahypoxia inducible factor 13091head and neck squamous cell carcinomaUM-22b----Data suggest that guggulsterone,a STAT3 inhibitor, primarily affects HIF-1a expression at the transcriptional level.19762335
RB1retinoblastoma 15925head and neck squamous cell carcinomaUM-22b----In UM-22b cells, expression levels of proteins that promote the transition from the G1 to the S phase of the cell cycle, including CDK4, CDK6, CDK2, phosphorylated Rb, cyclin E and cyclin D1,which is a target gene for both STAT3 and NFkappaB, showed modest decreases following 16 h of guggulsterone19762335
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774head and neck squamous cell carcinomaUM-22b----Guggulsterone was found to enhance STAT3 inhibition resulting from treatment of UM-22b cells with the small molecule EGFR inhibitor, erlotinib.19762335

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.