NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: glycyrrhizin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
JUNjun proto-oncogene3725HepatomaHep G2----Glycyrrhizin induced the AP-1/TATA reporter activity in a dose-dependent fashion, which was judged by chloramphenicol acetyltransferase assay and electrophoretic mobility-shift assay. Similar results were observed in HepG2 and Vero cells, suggested that glycyrrhizin effect was cell type independent. These results suggested that glycyrrhizin activated AP-1/TATA synthetic promoter in a dose-dependent manner, resulted in a 2.5-fold induction in HepG2 cell.11991252

 






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