Compound: Glaucocalyxin A

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

BAX

BCL2-associated X protein

Human promyelocytic leukemia

HL-60

After being normalized and verified with b-actin, Bax protein level was increased markedly in a time-dependent manner.

B-cell CLL/lymphoma 2

Human promyelocytic leukemia

HL-60

After being normalized and verified with b-actin, the expression of Bcl-2 was decreased significantly in a time-dependent manner.

caspase 3, apoptosis-related cysteine peptidase

Human promyelocytic leukemia

HL-60

Glaucocalyxin A treatment increased the activity of caspase-3 compared to vehicle-treated cell.

caspase 9, apoptosis-related cysteine peptidase

Human promyelocytic leukemia

HL-60

Glaucocalyxin A treatment increased the activity of caspase-9 compared to vehicle-treated cell.

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase