NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: geraniol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Prostate CancerPC-3----The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated.21371438
BCL2B-cell CLL/lymphoma 2596Prostate CancerPC-3----geraniol induces apoptosis and cell cycle arrest in vivo21371438
BCL2B-cell CLL/lymphoma 2596Prostate CancerPC-3----The expressions Bcl-2 was reduced in the cells treated with geraniol.21371438
BCL2L2BCL2-like 2599Prostate CancerPC-3----The expressions Bcl-w was reduced in the cells treated with geraniol.21371438
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 3664Prostate CancerPC-3----The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated.21371438
CASP3caspase 3, apoptosis-related cysteine peptidase836Prostate CancerPC-3----Caspase-3 activity was increased in relation to concentrations of geraniol in PC-3 cells.21371438
CCND1cyclin D1595Breast adenocarcinomaMCF-7----A significant, concentration-dependent decrease in expression of the early G1 phase cyclin D1 was observed in MCF-7 cells treated with geraniol.15450939
CCND1cyclin D1595Prostate CancerPC-3----The expressions Cyclin D was reduced in the cells treated with geraniol.21371438
CCNE1cyclin E1898Breast adenocarcinomaMCF-7----Protein levels of cyclin E decreased significantly in cells treated with geraniol at all concentrationSmM b-ionone.15450939
CCNE1cyclin E1898Prostate CancerPC-3----The expressions Cyclin E was reduced in the cells treated with geraniol.21371438
CDK1cyclin-dependent kinase 1983Prostate CancerPC-3----The expressions CDK1 was reduced in the cells treated with geraniol.21371438
CDK2cyclin-dependent kinase 21017Breast adenocarcinomaMCF-7----Protein levels of CDK 2, decreased significantly in cells treated with geraniol at all concentrations.15450939
CDK4cyclin-dependent kinase 41019Prostate CancerPC-3----The expressions CDK4 was reduced in the cells treated with geraniol.21371438
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Prostate CancerPC-3----The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated.21371438
CycACyclin A39340Breast adenocarcinomaMCF-7----Expression of cyclin A, the S phase CDK 2 activator, decreased significantly following treatment of cells with geraniol.15450939
CycACyclin A39340Prostate CancerPC-3----The expressions Cyclin A was reduced in the cells treated with geraniol.21371438
CycBCyclin B37618Prostate CancerPC-3----The expressions Cyclin B was reduced in the cells treated with geraniol.21371438
PSMD9proteasome (prosome, macropain) 26S subunit, non-ATPase, 95715Prostate CancerPC-3----The expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3) were markedly elevated.21371438

 






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