NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Genistein

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Gastric adenocarcinomaSG7901----Genistein 0.5, 1 and 1.5 mg/kg significantly inhibited carcinoma growth when it was injected near the tumor by 10.8%, 29.9% and 39.6%, respectively. The apoptosis index was increased progressively with increasing genistein dose (28.9% ± 1.2%, 33.8% ± 1.6% and 37.7% ± 1.2%) . The positive rate of bax protein was increased progressively (0.9% ± 1.7%, 24.9% ± 0.8% and 29.6% ± 1.7%) by by immunohistochemical staining, with increasing dose of genistein. The density of bax mRNA increased progressively with elongation of time by RT-PCR.18203299

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.