NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Gamma-Tocopherol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
PTGER3prostaglandin E receptor 3 (subtype EP3)5733Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.77.5±2 µM.---A marked increase of PGE2 generation was observed in RAW264.7 macrophage when cells were treated with 0.1 mg/ml LPS. Supplementation with gamma-Tocopherol led to a dose-dependent reduction of PGE2 synthesis.11005841
PTGER3prostaglandin E receptor 3 (subtype EP3)5733Lung adenocarcinomaA5494 µM.---A marked reducetion of PGE2 synthesis was observed in IL-1-beta-treated A549 human epithelial cells.11005841

 






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