NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Gallic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Gastric CancerAGS----The protein levels of AKT-1, decreased after AGS cell treated with gallic acid.20600540
AKT1v-akt murine thymoma viral oncogene homolog 1207Gastric CancerAGS----The protein levels of P-AKT, decreased after AGS cell treated with gallic acid.20600540
CDC42cell division cycle 42 (GTP binding protein, 25kDa)998Gastric CancerAGS----After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed protein levels of cdc42 decreased in a dose-dependent manner.20600540
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon9641Gastric CancerAGS----AGS cells were treated with or without different concentrations of gallic acid (2.0-3.5 µM) for 48 h. the protein levels of IjB increased in a dose-dependent manner.20600540
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)4313Gastric CancerAGS----MMP-9 activity was markedly reduced with GA. The inhibitory effects were more significant at concentrations of 2.5 and 3.5µM.GA presents a strong suppression on AGS cell growth and MMP secretion. GA possesses almost 600 times higher suppressive effect on MMP secretion than Caffic acid and Protocatechuic acid.20600540
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Gastric CancerAGS----MMP-2 activity was markedly reduced with GA. The inhibitory effects were more significant at concentrations of 2.5 and 3.5µM.GA presents a strong suppression on AGS cell growth and MMP secretion. GA possesses almost 600 times higher suppressive effect on MMP secretion than Caffic acid and Protocatechuic acid.20600540
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Gastric CancerAGS----Gallic acid inhibited the migration of AGS cells by inhibition NFKB activity and downregulation of PI3 K/AKT pathway.20600540
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha5290Gastric CancerAGS----The protein levels of PI3K, decreased after AGS cell treated with gallic acid.20600540
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)5879Gastric CancerAGS----After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed showed protein levels of Rac1 decreased in a dose-dependent manner.20600540
RHOAras homolog family member A387Gastric CancerAGS----After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed showed protein levels of RhoA decreased in a dose-dependent manner.20600540
RHOBras homolog family member B388Gastric CancerAGS----After treatment of AGS cells witht different concentrations of gallic acid (2.0-3.5 µM) for 48 h, the results showed showed protein levels of RhoB increased in a dose-dependent manner.20600540
SULT1A3sulfotransferase family, cytosolic, 1A, phenol-preferring, member 36818HepatomaHep G2----Gallic acid was found to increase PST-P activity. Gallic acid inducing PST-P activity, in a concentration-dependent manner, in concentrations of 10-50 µM, with a maximum of 4-5-fold induction. Gallic acid, a trihydroxybenzoic acid, has been found to cause a significant increase in the activity of PST-P. PST-P mRNA expression was induced markedly by gallic acid, in a dose-responsive manner. A maximum of 4.6-fold mRNA expression was observed at 50 µM. A marked induction of PST-P mRNA expression, by gallic acid, was observed after 6 h of exposure; maximum induction of PST-P mRNA expression was observed at 12 h after the addition of 50 µM gallic acid. PST-P protein was markedly induced by gallic acid, in a dose response manner, at concentrations of 10-50 µM. A maximum of 3.5-fold induction was observed at 50 µM.Significant (p <0.05) induction of PST-P protein was observed 24 h after the addition of 50 µM gallic acid. The enhanced PST-P protein expression in HepG2 cells, after treatment with gallic acid, corresponded to the induction of PST-P activity , suggesting that the observed induction of PST-P activity, by gallic acid, is due to increased PST-P protein synthesis, through activation of gene transcription.15941313

 






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