NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Galangin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AHRaryl hydrocarbon receptor196Breast CarcinomaHs578T----Galangin is a potent inhibitor of the aryl hydrocarbon receptor (AhR), an environmental carcinogen-responsive transcription factor implicated in mammary tumor initiation and growth control. Galangin would effect a change in mammary tumor cell proliferation through inhibition of AhR activity. Galangin was shown to both inhibit AhR activity and to block cell.16569260
BAXBCL2-associated X protein581HepatomaHep G2----Treatment with galangin induced apoptosis by translocating the pro-apoptotic protein Bax to the mitochondria, which released apoptosis-inducing factor and cytochrome c and AIF into the cytosol.Bax levels in the mitochondrial fraction of galangin-treated HCC cells increased in a dose-dependent manner, suggesting that the translocation of Bax into the mitochondria was involved in cell death induced by galangi.20632439
CASP3caspase 3, apoptosis-related cysteine peptidase836HepatomaHep G2----A concomitant increase of caspase-3 activation was observed with western blotting.20632439
CASP9caspase 9, apoptosis-related cysteine peptidase842HepatomaHep G2----Caspase-9 activation in a dose-dependent manner in hepatocellular carcinoma cell line.20632439
CCND3Cyclin D3896Breast CarcinomaHs578T----Galangin inhibited transition of cells from the G0/G1 to the S phases of cell growth, likely through the nearly total elimination of cyclin D.16569260
CycACyclin A39340Breast CarcinomaHs578T----galangin significantly reduced expression of cyclins A (p < 0.001) and E (p < 0.02).16569260
PARP1poly (ADP-ribose) polymerase 1142HepatomaHep G2----A concomitant increase of PARP celavage was observed with western blotting.20632439
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-40±3 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-50±6 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.