NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Flavone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Lung adenocarcinomaA549----Flavone induces a cyclin-dependent kinase inhibitor, p21/WAF1, without increasing the p53 protein level which results in dephosphorylation of the RB protein which is involved in the G1 phase arrest.Treatment with 100 WM £avone induced p21/WAF1 protein 12 h after exposure, and a strong induction of p21/WAF1 protein was observed from 24 h to 48 h after exposure.9804172

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.