NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Flavone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Lung adenocarcinomaA549----Flavone induces a cyclin-dependent kinase inhibitor, p21/WAF1, without increasing the p53 protein level which results in dephosphorylation of the RB protein which is involved in the G1 phase arrest.Treatment with 100 WM £avone induced p21/WAF1 protein 12 h after exposure, and a strong induction of p21/WAF1 protein was observed from 24 h to 48 h after exposure.9804172
PSMD9proteasome (prosome, macropain) 26S subunit, non-ATPase, 95715Lung adenocarcinomaA549----It was investigated the induction in A549 cells of another CDK inhibitor, p27, but only slight induction was observed upon treatment with flavone.9804172
RB1retinoblastoma 15925Lung adenocarcinomaA549----When A549 cells were exposed to 100 µM flavone for 12-48 h, the majority of the RB protein molecules was converted to the hypophosphorylated form. These results suggest that the G1 phase arrest caused by flavone is due to dephosphorylation of the RB protein.9804172

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.