| CDK4 | cyclin-dependent kinase 4 | 1019 | Colon Cancer | HT-29 | - | - | - | - | CDK4 activity was drastically decreased within 30 min of Fisetin treatment, which was consistently lower in Fisetin-treated cells throughout the 12-h incubation period (P< 0.05).Fisetin also inhibited CDk4 activity in a cell-free system (P < 0.05), indicating that it may directly inhibit CDk4 activity. | 16317137 |