NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Ferulic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
GSTM1glutathione S-transferase mu 12944Colon carcinogenesis-----GST activity in the liver was signifcantly elevated by gavage of Ferulic acid(FA) at a dose of 100 mg/kg body weight (P< 0.03). It significantly increased the activities of detoxification enzymes GST and QR in the liver and/or colonic mucosa. Thus, such evidence for the activity on the detoxifying enzymes may also be related to the blocking effect of FA on AOM-induced colon carcinogenesis.10893437
NQO1NAD(P)H dehydrogenase, quinone 11728Colon carcinogenesis-----Ferulic acid(FA) administration at 100mg/kg dose signifcantly elevated QR activity in the colonic mucosa or liver (P< 0.02, P< 0<01, respectively). It significantly increased the activities of detoxification enzymes GST and QR in the liver and/or colonic mucosa. Thus, such evidence for the activity on the detoxifying enzymes may also be related to the blocking effect of FA on AOM-induced colon carcinogenesis.10893437

 






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