Compound: Farnesol

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

ATF3

activating transcription factor 3

467

Lung Cancer

H-460

Analysis showed that FOH induced the expression of a great number of genes typically associated with ER stress response signaling, including ATF3.

17699800

CASP3

caspase 3, apoptosis-related cysteine peptidase

836

Lung Cancer

H-460

Examination of caspase activation in FOH-treated H460 cells showed that caspase-3 was significantly activated at 4 h, similar to the time course of poly(ADP-ribose) polymerase (PARP) cleavage.

17699800

CASP9

caspase 9, apoptosis-related cysteine peptidase

842

Lung Cancer

H-460

Examination of caspase activation in FOH-treated H460 cells showed that caspase-9 were significantly activated at 4 h, similar to the time course of poly(ADP-ribose) polymerase (PARP) cleavage.

17699800

EGR1

early growth response 1

1958

Lung Cancer

H-460

FOH also induces the expression of several members of the Egr family, transcription factors that are important regulators of apoptosis and cell proliferation including Egr1.

17699800

FOS

FBJ murine osteosarcoma viral oncogene homolog

2353

Lung Cancer

H-460

The expression of several members of the Fos were also greatly upregulated witht the FOH treatment.

17699800

JUN

jun proto-oncogene

3725

Lung Cancer