NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Eriodictyol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 36197preneoplastic epidermal keratinocytesJB6 C141----Docking experiments using the crystal structure of the RSK2 N-terminal kinase domain combined with in vitro pulldown assays demonstrated that eriodictyol, bound with the N-terminal kinase domain of RSK2 to inhibit RSK2 N-terminal kinase activity. RSK2-ATF1 signaling plays an important role in neoplastic cell transformation and that eriodictyol is a novel natural compound for suppressing RSK2 kinase activity21098035
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-4±0.3 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-6±1 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415

 






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