| XIAP | X-linked inhibitor of apoptosis | 331 | T cell leukemia | Jurkat T | - | - | - | - | Treatment with ergolide, a sesquiterpene lactone from Inula britannica var chinensis, caused theinduction of apoptosis in Jurkat T cells, which was confirmed by DNA fragmentation, caspase-3activation and cleavage of poly(ADP-ribose) polymerase in response to ergolide. Furthermore,mitochondrial dysfunction appeared to be associated with ergolide-induced apoptosis, becauseBax translocation and cytochrome c release were stimulated by ergolide. In parallel, the nuclearfactor- B (NF- B) signaling pathway was significantly inhibited by ergolide, which was accompaniedby down-regulation of cell survival molecules, such as X-chromosome-linked inhibitor of apoptosisand Bcl-2. | 16354403 |