NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Ergolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836T cell leukemiaJurkat T----Treatment with ergolide, a sesquiterpene lactone from Inula britannica var chinensis, caused theinduction of apoptosis in Jurkat T cells, which was confirmed by DNA fragmentation, caspase-3activation and cleavage of poly(ADP-ribose) polymerase in response to ergolide. Furthermore,mitochondrial dysfunction appeared to be associated with ergolide-induced apoptosis, becauseBax translocation and cytochrome c release were stimulated by ergolide. In parallel, the nuclearfactor- B (NF- B) signaling pathway was significantly inhibited by ergolide, which was accompaniedby down-regulation of cell survival molecules, such as X-chromosome-linked inhibitor of apoptosisand Bcl-2.16354403

 






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