NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Epigallocatechin gallate

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon CancerHT-29----After the treatments of different doses of Epigallocatechin gallate (EGCG) , the induction of caspase-3 activity in HT-29 cells was consistent with the results shown in DAPI staining and DNA fragmentation experiments. 100 mM of EGCG led to ~8-fold induction of caspase-3 activity after 24 h treatment.12819184
CASP9caspase 9, apoptosis-related cysteine peptidase842Colon CancerHT-29----During the 24 h period, the activity of caspase-9 was consistently increased with the treatment of Epigallocatechin gallate (EGCG).12819184
MAPK1mitogen-activated protein kinase 15594Colon CancerHT-29----ERK was phosphorylated and activated time-dependently in HT-29 cells after Epigallocatechin gallate (EGCG) treatments.12819184
MAPK1mitogen-activated protein kinase 15594Colon CancerHT-29----p38 was phosphorylated and activated time-dependently in HT-29 cells after Epigallocatechin gallate (EGCG) treatments.12819184
MAPK8mitogen-activated protein kinase 85599Colon CancerHT-29----JNK was phosphorylated and activated time-dependently in HT-29 cells after Epigallocatechin gallate (EGCG) treatments.12819184
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit5564Colon CancerHT-29----EGCG activated AMPK in a dose-dependent manner as shown by the increased phosphorylation of ACC (acetyl-CoA carboxylase) and the elevation of AMPK expression.16797120
SLC2A1solute carrier family 2 6513Colon CancerHT-29----Epigallocatechin gallate distinctively reduced mRNA levels of Glut-116797120
VEGFAvascular endothelial growth factor A7422Colon CancerHT-29----Epigallocatechin gallate distinctively reduced mRNA levels of VEGF genes16797120

 






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