NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: ellagic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Bladder CancerT24----The data also indicated that activation of caspase-3 contributed to ellagic acid-induced apoptosis in T24 cells.15868936
CDK2cyclin-dependent kinase 21017Bladder CancerT24----The data demonstrated that 1-50 µM ellagic acid increased p53 and p21 levels and decreased CDK2 levels. These effects of ellagic acid on p53, p21 and CDK2 were also dose-dependen.15868936
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Cervical CancerCaSki----ellagic acid induce an increase in the expression of both p21 mRNA and protein10355751
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Bladder CancerT24----The data demonstrated that 1-50 µM ellagic acid increased p53 and p21 levels and decreased CDK2 levels. These effects of ellagic acid on p53, p21 and CDK2 were also dose-dependen.15868936
TP53tumor protein p537157Bladder CancerT24----The data demonstrated that 1-50 µM ellagic acid increased p53 and p21 levels and decreased CDK2 levels. These effects of ellagic acid on p53, p21 and CDK2 were also dose-dependen.15868936

 






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