NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: digitoxin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
TOP2Atopoisomerase (DNA) II alpha 170kDa7153Breast adenocarcinomaMCF-7----In vitro experiments showed that 1 at 30 nM induced levels of DNA topoisomerase II cleavable complexes similar to etoposide, a topoisomerase II poison widely used in cancer chemotherapy. Using the individual cell assay TARDIS, cells exposed to 1 for 30 min showed low but statistically significant levels of DNA topoisomerase II cleavable complexes; however these complexes disappeared after 24 h exposur.16309315
TOP2Atopoisomerase (DNA) II alpha 170kDa7153LeukemiaK-562----In vitro experiments showed that 1 at 30 nM induced levels of DNA topoisomerase II cleavable complexes similar to etoposide, a topoisomerase II poison widely used in cancer chemotherapy. Using the individual cell assay TARDIS, cells exposed to 1 for 30 min showed low but statistically significant levels of DNA topoisomerase II cleavable complexes; however these complexes disappeared after 24 h exposur.16309315
TOP2Atopoisomerase (DNA) II alpha 170kDa7153MelanomaUACC-62----In vitro experiments showed that 1 at 30 nM induced levels of DNA topoisomerase II cleavable complexes similar to etoposide, a topoisomerase II poison widely used in cancer chemotherapy. Using the individual cell assay TARDIS, cells exposed to 1 for 30 min showed low but statistically significant levels of DNA topoisomerase II cleavable complexes; however these complexes disappeared after 24 h exposur.16309315
TOP2Atopoisomerase (DNA) II alpha 170kDa7153Renal cancerTK-10----In vitro experiments showed that 1 at 30 nM induced levels of DNA topoisomerase II cleavable complexes similar to etoposide, a topoisomerase II poison widely used in cancer chemotherapy. Using the individual cell assay TARDIS, cells exposed to 1 for 30 min showed low but statistically significant levels of DNA topoisomerase II cleavable complexes; however these complexes disappeared after 24 h exposur.16309315

 






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