NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Digitoxin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

SRC

v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

6714

Breast Carcinoma

MDA-MB-453

-

-

-

-

Treatment of serum-starved MDA-MB-453 cells with digitoxin at 80 µg/ml (105 µM) for 30 min increased the level of p-Src by 1.5-fold.

18755149

TOP2A

topoisomerase (DNA) II alpha 170kDa

7153

Breast adenocarcinoma

MCF-7

-

-

-

-

In vitro experiments showed that 1 at 30 nM induced levels of DNA topoisomerase II cleavable complexes similar to etoposide, a topoisomerase II poison widely used in cancer chemotherapy. Using the individual cell assay TARDIS, cells exposed to 1 for 30 min showed low but statistically significant levels of DNA topoisomerase II cleavable complexes; however these complexes disappeared after 24 h exposur.

16309315

TOP2A

topoisomerase (DNA) II alpha 170kDa

7153

Leukemia

K-562

-

-

-

-

In vitro experiments showed that 1 at 30 nM induced levels of DNA topoisomerase II cleavable complexes similar to etoposide, a topoisomerase II poison widely used in cancer chemotherapy. Using the individual cell assay TARDIS, cells exposed to 1 for 30 min showed low but statistically significant levels of DNA topoisomerase II cleavable complexes; however these complexes disappeared after 24 h exposur.

16309315

TOP2A

topoisomerase (DNA) II alpha 170kDa

7153

Melanoma

UACC-62

-

-

-

-

In vitro experiments showed that 1 at 30 nM induced levels of DNA topoisomerase II cleavable complexes similar to etoposide, a topoisomerase II poison widely used in cancer chemotherapy. Using the individual cell assay TARDIS, cells exposed to 1 for 30 min showed low but statistically significant levels of DNA topoisomerase II cleavable complexes; however these complexes disappeared after 24 h exposur.

16309315

TOP2A

topoisomerase (DNA) II alpha 170kDa

7153

Renal cancer

TK-10

-

-

-

-

In vitro experiments showed that 1 at 30 nM induced levels of DNA topoisomerase II cleavable complexes similar to etoposide, a topoisomerase II poison widely used in cancer chemotherapy. Using the individual cell assay TARDIS, cells exposed to 1 for 30 min showed low but statistically significant levels of DNA topoisomerase II cleavable complexes; however these complexes disappeared after 24 h exposur.

16309315

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.