NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Diarctigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
PTGER3prostaglandin E receptor 3 (subtype EP3)5733Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----we demonstrated that diarctigenin inhibited the production of NO, prostaglandin E2, tumor necrosis factor- , and interleukin (IL)-1 and IL-6 with IC50 values of 6 to 12 M in zymosan- or lipopolysaccharide- (LPS) activated macrophage.18694995

 






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