NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Dehydrocostuslactone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
JAK1Janus kinase 13716LeukimiaTHP-1----Pre-treatment with 6-25 mM Dehydrocostuslactone for 30 minutes resulted in almost complete dephosphorylation of kinases.21625597
JAK2Janus kinase 23717LeukimiaTHP-1----Pre-treatment with 6-25 mM Dehydrocostuslactone for 30 minutes resulted in almost complete dephosphorylation of kinases.21625597
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774LeukimiaTHP-1-10 mM--The administration of DCE to 25 mM 30 minutes was able to inhibit in a concentration-dependent manner STAT3 DNA-binding activity with estimated EC50 value of 10 mM.21625597

 






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