NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: D-delta-tocotrienol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Lung adenocarcinomaA549----the expressions of MMP9 in both cell lines were significantly inhibited on treatment with delta-tocotienol.21598300
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Lung adenocarcinomaH1299----the expressions of MMP9 in both cell lines were significantly inhibited on treatment with delta-tocotienol.21598300
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Lung adenocarcinomaA549----The results clearly demonstrate that delta-tocotrienol inhibited NF-kB activity and its target genes expressions.21598300
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Lung adenocarcinomaH1299----The results clearly demonstrate that delta-tocotrienol inhibited NF-kB activity and its target genes expressions.21598300
VEGFAvascular endothelial growth factor A7422Lung adenocarcinomaA549----the expressions of VEGF in both cell lines were significantly inhibited on treatment with delta-tocotienol.21598300
VEGFAvascular endothelial growth factor A7422Lung adenocarcinomaH1299----the expressions of VEGF in both cell lines were significantly inhibited on treatment with delta-tocotienol.21598300

 






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