NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Daidzein

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Breast adenocarcinomaMCF-7----The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax,as revealed by western blottin.19013426
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast CarcinomaHs578T----It induced cell apoptosis through a caspase-3-dependent pathway and mediated cell cycle arrest in the G2/M phase. The induction of apoptosis in the breast cancer cell lines by genistein isoflavone confirmed by detection of increased caspase-3 activity in the isoflavone-treated HS578T and MDA-MB-231 cells.19013426
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast CarcinomaMDA-MB-231----It induced cell apoptosis through a caspase-3-dependent pathway and mediated cell cycle arrest in the G2/M phase. The induction of apoptosis in the breast cancer cell lines by genistein isoflavone confirmed by detection of increased caspase-3 activity in the isoflavone-treated HS578T and MDA-MB-231 cells.19013426
CASP9caspase 9, apoptosis-related cysteine peptidase842Breast adenocarcinomaMCF-7----The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax,as revealed by western blottin.19013426
CDK2cyclin-dependent kinase 21017Human MelanomaOCM-1----Daidzein, which induced a cell cycle block in G1, inhibited the activity of CDK-2 by 40-60%.11322924
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Human MelanomaOCM-1----Daidzein, which inhibited CDK2 and induced a G1 block, up-regulated p21CIP1.11322924
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Breast adenocarcinomaMCF-7----The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax,as revealed by western blottin.19013426
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)1027Human MelanomaOCM-1----Daidzein, which inhibited CDK2 and induced a G1 block, up-regulated p21CIP1 and, to a lower extent, p27KIP.11322924
TP53tumor protein p537157Breast adenocarcinomaMCF-7----The serum metabolites of Puerariae radix inhibited cell proliferation via an up-regulation of p21/Waf1, p53, caspase-9, and Bax,as revealed by western blottin.19013426

 






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